InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADM

Summary

InnateDB Protein

IDBP-584340.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADM

Protein Name

adrenomedullin

Synonyms

AM; PAMP;

Species

Homo sapiens

Ensembl Protein

ENSP00000435124

InnateDB Gene

IDBG-31636 (ADM)

Protein Structure

UniProt Annotation

Function

AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding

Biological Process

GO:0001570	vasculogenesis
GO:0002031	G-protein coupled receptor internalization
GO:0006171	cAMP biosynthetic process
GO:0006701	progesterone biosynthetic process
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008015	blood circulation
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0045906	negative regulation of vasoconstriction