InnateDB Protein
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IDBP-584679.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LIMA1
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Protein Name
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LIM domain and actin binding 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000450266
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InnateDB Gene
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IDBG-32504 (LIMA1)
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Protein Structure
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Function |
Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. {ECO:0000269PubMed:12566430}.
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Subcellular Localization |
Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=This cytoskeletal protein co- localizes with actin stress fibers and focal adhesion plaques.
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Disease Associations |
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Tissue Specificity |
Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
30
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001781
Zinc finger, LIM-type
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PFAM |
PF00412
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PRINTS |
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PIRSF |
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UHB6
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PhosphoSite |
PhosphoSite-Q9UHB6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51474
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UniGene |
Hs.525419
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RefSeq |
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HUGO |
HGNC:24636
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OMIM |
608364
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CCDS |
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HPRD |
09755
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IMGT |
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EMBL |
AB209512
AF157325
AF198454
AF198455
AF218025
AK000057
AK000335
AK000372
AK023649
AK314447
AL136911
BC001247
BC010664
BC110815
BC136763
CH471111
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GenPept |
AAF23755
AAF23756
AAF67491
AAG17267
AAH01247
AAH10664
AAI10816
AAI36764
BAA90914
BAA91092
BAA91120
BAB14625
BAD92749
BAG37056
CAB66845
EAW58135
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