InnateDB Protein
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IDBP-584875.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCAR1
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Protein Name
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cell division cycle and apoptosis regulator 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000439252
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InnateDB Gene
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IDBG-76172 (CCAR1)
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Protein Structure
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Function |
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. {ECO:0000250, ECO:0000269PubMed:12816952}.
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Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000269PubMed:12816952}.
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Disease Associations |
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Tissue Specificity |
Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. {ECO:0000269PubMed:12816952}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003034
SAP domain
IPR012340
Nucleic acid-binding, OB-fold
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PFAM |
PF02037
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PRINTS |
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PIRSF |
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SMART |
SM00513
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IX12
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PhosphoSite |
PhosphoSite-Q8IX12
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TrEMBL |
F5H1H2
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UniProt Splice Variant |
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Entrez Gene |
55749
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UniGene |
Hs.664559
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RefSeq |
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HUGO |
HGNC:24236
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OMIM |
612569
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CCDS |
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HPRD |
10811
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IMGT |
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EMBL |
AF465616
AK000741
AK001452
AK001701
AK023438
AK292649
AK298004
AK299307
AL391539
AL513534
AY249140
BC015475
BC026036
BC089420
BC108682
BC130626
BC132725
CH471083
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GenPept |
AAH15475
AAH26036
AAH89420
AAI08683
AAI30627
AAI32726
AAO17319
AAP82002
BAA91354
BAA91700
BAA91847
BAB14574
BAF85338
BAG60310
BAG61320
CAH70221
CAH73835
EAW54302
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