Version 5.4
Homo sapiens Protein: PITPNM2
Summary
InnateDB Protein IDBP-585217.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PITPNM2
Protein Name phosphatidylinositol transfer protein, membrane-associated 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000437611
InnateDB Gene IDBG-63232 (PITPNM2)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269PubMed:10022914}.
Subcellular Localization Endomembrane system {ECO:0000269PubMed:22361696}; Peripheral membrane protein {ECO:0000269PubMed:22361696}.
Disease Associations
Tissue Specificity Highly expressed in brain, heart, ovary, testis and thymus. Detected in small intestine, prostate, pancreas, skeletal muscle, liver, colon and placenta. {ECO:0000269PubMed:10022914}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0008289 lipid binding
GO:0046872 metal ion binding
Biological Process
GO:0006810 transport
GO:0008152 metabolic process
Cellular Component
GO:0005622 intracellular
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR001666 Phosphatidylinositol transfer protein
IPR004177 DDHD
IPR013209 LNS2, Lipin/Ned1/Smp2
IPR023214 HAD-like domain
PFAM PF02121
PF02862
PF08235
PF00702
PF08282
PF13419
PRINTS PR00391
PIRSF
SMART SM00775
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZ72
PhosphoSite PhosphoSite-Q9BZ72
TrEMBL Q9UF51
UniProt Splice Variant
Entrez Gene 57605
UniGene Hs.272759
RefSeq
HUGO HGNC:21044
OMIM 608920
CCDS CCDS9242
HPRD 08335
IMGT
EMBL AB040890 AC026362 AC073857 AF334585 AL133612
GenPept AAK01445 BAA95981 CAB63741

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca