InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRRC59

Summary

InnateDB Protein

IDBP-58531.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRRC59

Protein Name

leucine rich repeat containing 59

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000225972

InnateDB Gene

IDBG-58529 (LRRC59)

Protein Structure

UniProt Annotation

Function

Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. {ECO:0000269PubMed:22321063}.

Subcellular Localization

Microsome membrane {ECO:0000250}; Single- pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11964394}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

Cellular Component

GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042645	mitochondrial nucleoid