Version 5.4
Homo sapiens Protein: LY75
Summary
InnateDB Protein IDBP-585366.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LY75
Protein Name lymphocyte antigen 75
Synonyms CD205; CLEC13B; DEC-205; GP200-MR6; LY-75;
Species Homo sapiens
Ensembl Protein ENSP00000451446
InnateDB Gene IDBG-73297 (LY75)
Protein Structure
UniProt Annotation
Function Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells. {ECO:0000269PubMed:12824192, ECO:0000269PubMed:9862343}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0030246 carbohydrate binding
Biological Process
GO:0006897 endocytosis
GO:0006954 inflammatory response
GO:0006955 immune response
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60449
PhosphoSite PhosphoSite-O60449
TrEMBL
UniProt Splice Variant
Entrez Gene 9936
UniGene
RefSeq NP_001185693
HUGO HGNC:30843
OMIM 612246
CCDS CCDS74595
HPRD 05161
IMGT
EMBL AC009961 AC093873 AF011333 AF064827 AY184222 AY314006
GenPept AAC17636 AAC62622 AAN85434 AAP79899 AAY14943 AAY24189

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca