InnateDB Protein
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IDBP-585963.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ELP2
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Protein Name
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elongation protein 2 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000443800
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InnateDB Gene
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IDBG-2565 (ELP2)
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Protein Structure
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Function |
Regulates the ligand-dependent activation of STAT3. {ECO:0000250}.Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. {ECO:0000269PubMed:11714725, ECO:0000269PubMed:11818576}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0006325
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chromatin organization
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006368
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transcription elongation from RNA polymerase II promoter
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GO:0045087
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innate immune response (InnateDB)
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Cellular Component |
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PDB ID |
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q6IA86
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PhosphoSite |
PhosphoSite-Q6IA86
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55250
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UniGene |
Hs.8739
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RefSeq |
NP_001229807
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HUGO |
HGNC:18248
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OMIM |
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CCDS |
CCDS56068
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HPRD |
15443
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IMGT |
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EMBL |
AC023043
AC091060
AF332505
AF403223
AK001741
AK022709
AK222791
AK293051
AK300201
AK302062
BC009211
BC032553
CR457269
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GenPept |
AAH09211
AAH32553
AAK97355
AAQ03093
BAA91874
BAB14193
BAD96511
BAF85740
BAG61972
BAG63452
CAG33550
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