Version 5.4
Homo sapiens Protein: MANF
Summary
InnateDB Protein IDBP-586197.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MANF
Protein Name mesencephalic astrocyte-derived neurotrophic factor
Synonyms ARMET; ARP;
Species Homo sapiens
Ensembl Protein ENSP00000432799
InnateDB Gene IDBG-37323 (MANF)
Protein Structure
UniProt Annotation
Function Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. {ECO:0000250, ECO:0000269PubMed:12794311, ECO:0000269PubMed:18561914}.
Subcellular Localization Secreted {ECO:0000269PubMed:12794311, ECO:0000269PubMed:18561914}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
GO:0006986 response to unfolded protein
GO:0008150 biological_process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR011001 Saposin-like
IPR019345 Armet protein
PFAM PF10208
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P55145
PhosphoSite PhosphoSite-P55145
TrEMBL A8K878
UniProt Splice Variant
Entrez Gene 7873
UniGene
RefSeq NP_006001
HUGO HGNC:15461
OMIM 601916
CCDS CCDS46836
HPRD 03558
IMGT
EMBL AC092037 AK292243 BC007282 BC113588 BC113590 BT007110 M83751
GenPept AAB08753 AAH07282 AAI13589 AAI13591 AAP35774 BAF84932

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca