Version 5.4
Homo sapiens Protein: CNIH2
Summary
InnateDB Protein IDBP-58620.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNIH2
Protein Name cornichon homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000310003
InnateDB Gene IDBG-58618 (CNIH2)
Protein Structure
UniProt Annotation
Function Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. {ECO:0000269PubMed:20805473}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.
Disease Associations
Tissue Specificity Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). {ECO:0000269PubMed:23103966}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0035249 synaptic transmission, glutamatergic
GO:0035556 intracellular signal transduction
GO:0042391 regulation of membrane potential
GO:0051668 localization within membrane
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR003377 Cornichon
PFAM PF03311
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PI25
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 254263
UniGene Hs.437072
RefSeq NP_872359
HUGO HGNC:28744
OMIM 611288
CCDS CCDS8131
HPRD 13078
IMGT
EMBL BC047953
GenPept AAH47953

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca