InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIR3DL1

Summary

InnateDB Protein

IDBP-586608.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIR3DL1

Protein Name

killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1

Synonyms

CD158E1; KIR; KIR3DL1/S1; NKAT-3; NKAT3; NKB1; NKB1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000443350

InnateDB Gene

IDBG-69578 (KIR3DL1)

Protein Structure

UniProt Annotation

Function

Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. {ECO:0000269PubMed:22020283}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	5 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030109	HLA-B specific inhibitory MHC class I receptor activity

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0050776	regulation of immune response

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR013151 Immunoglobulin

PFAM

PF00047

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P43629

PhosphoSite

PhosphoSite-P43629

TrEMBL

F6QF33

UniProt Splice Variant

Entrez Gene

3811

UniGene

Hs.645228

RefSeq

HUGO

HGNC:6338

OMIM

604946

CCDS

HPRD

10034

IMGT

EMBL

AC006293 AC011501 AF022049 L41269 L76664 U30273 U30274 U31416 X94262

GenPept

AAA69870 AAB36592 AAB52521 AAB52522 AAB95322 AAC23725 CAA63938