Version 5.4
Homo sapiens Protein: SUDS3
Summary
InnateDB Protein IDBP-587415.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUDS3
Protein Name suppressor of defective silencing 3 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000443988
InnateDB Gene IDBG-59847 (SUDS3)
Protein Structure
UniProt Annotation
Function Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269PubMed:12724404, ECO:0000269PubMed:21239494}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21239494}.
Disease Associations
Tissue Specificity Expressed in various cancer cell ines. {ECO:0000269PubMed:12724404}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0016575 histone deacetylation
GO:0021762 substantia nigra development
GO:0043065 positive regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016580 Sin3 complex
Protein Structure and Domains
PDB ID
InterPro IPR013907 Sds3-like
PFAM PF08598
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H7L9
PhosphoSite PhosphoSite-Q9H7L9
TrEMBL Q52LB7
UniProt Splice Variant
Entrez Gene 64426
UniGene Hs.653927
RefSeq NP_071936
HUGO HGNC:29545
OMIM 608250
CCDS CCDS44993
HPRD 12196
IMGT
EMBL AK023801 AK024460 BC030252 BC093990 BC098404 BC112000
GenPept AAH30252 AAH93990 AAH98404 AAI12001 BAB14685 BAB15750

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca