InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HDHD1

Summary

InnateDB Protein

IDBP-587503.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDHD1

Protein Name

haloacid dehalogenase-like hydrolase domain containing 1

Synonyms

DXF68S1E; FAM16AX; GS1; HDHD1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000441208

InnateDB Gene

IDBG-41943 (HDHD1)

Protein Structure

UniProt Annotation

Function

Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine. {ECO:0000269PubMed:20722631}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0016791	phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0008150	biological_process
GO:0009117	nucleotide metabolic process
GO:0016311	dephosphorylation

Cellular Component

GO:0070062

extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR023214 HAD-like domain

PFAM

PF00702
PF08282
PF13419

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08623

PhosphoSite

PhosphoSite-Q08623

TrEMBL

E7EVH9

UniProt Splice Variant

Entrez Gene

8226

UniGene

Hs.185910

RefSeq

NP_001171606

HUGO

HGNC:16818

OMIM

306480

CCDS

CCDS55366

HPRD

02383

IMGT

EMBL

AC073583 AK223405 AK300740 AK300985 AK313155 BC012494 CH471074 DR156836 M86934

GenPept

AAA58622 AAH12494 BAD97125 BAG35973 BAG62605 BAH13339 EAW98748