InnateDB Protein
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IDBP-588293.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POSTN
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Protein Name
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periostin, osteoblast specific factor
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Synonyms
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OSF-2; OSF2; PDLPOSTN; periostin; PN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000437959
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InnateDB Gene
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IDBG-24971 (POSTN)
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Protein Structure
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Function |
Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. {ECO:0000250, ECO:0000269PubMed:12235007, ECO:0000269PubMed:18450759}.
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Subcellular Localization |
Golgi apparatus {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:12235007}. Note=Colocalizes with BMP1 in the Golgi. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers. {ECO:0000269PubMed:11550156, ECO:0000269PubMed:12235007, ECO:0000269PubMed:15082792, ECO:0000269PubMed:23946676}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000782
FAS1 domain
IPR011489
EMI domain
IPR016666
TGF beta-induced protein bIGH3/osteoblast-specific factor 2
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PFAM |
PF02469
PF07546
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PRINTS |
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PIRSF |
PIRSF016553
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SMART |
SM00554
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TIGRFAMs |
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Modification |
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SwissProt |
Q15063
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PhosphoSite |
PhosphoSite-Q15063
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10631
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UniGene |
Hs.721018
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RefSeq |
NP_001129408
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HUGO |
HGNC:16953
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OMIM |
608777
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CCDS |
CCDS53864
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HPRD |
12295
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IMGT |
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EMBL |
AL138679
AL646087
AY140646
AY918092
BC106709
BC106710
CH471075
D13665
D13666
EU262883
EU262884
EU262886
GU354210
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GenPept |
AAI06710
AAI06711
AAN17733
AAY15840
ABY86630
ABY86631
ABY86633
ADA79517
BAA02836
BAA02837
CAH70104
CAH70107
CAH73568
CAH73569
EAX08590
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