Version 5.4
Homo sapiens Protein: AKIP1
Summary
InnateDB Protein IDBP-588445.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKIP1
Protein Name A kinase (PRKA) interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000431331
InnateDB Gene IDBG-30938 (AKIP1)
Protein Structure
UniProt Annotation
Function Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. {ECO:0000269PubMed:18178962, ECO:0000269PubMed:20562110}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15630084, ECO:0000269PubMed:18178962}. Note=Locates to punctate spots.
Disease Associations
Tissue Specificity Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up- regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain. {ECO:0000269PubMed:12527432, ECO:0000269PubMed:15630084}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NQ31
PhosphoSite PhosphoSite-Q9NQ31
TrEMBL E9PPN7
UniProt Splice Variant
Entrez Gene 56672
UniGene
RefSeq
HUGO HGNC:1170
OMIM 609191
CCDS CCDS7793
HPRD 12380
IMGT
EMBL AC026894 AF493783 AF493784 AF493785 AF493786 AF512007 AJ400877 AK075308 BC030996
GenPept AAH30996 AAM12862 AAM12863 AAM12864 AAM12865 AAM12866 AAM12867 AAM34785 BAC11537 CAB92290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca