InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGEF12

Summary

InnateDB Protein

IDBP-588671.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF12

Protein Name

Rho guanine nucleotide exchange factor (GEF) 12

Synonyms

LARG; PRO2792;

Species

Homo sapiens

Ensembl Protein

ENSP00000432984

InnateDB Gene

IDBG-74643 (ARHGEF12)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001478 PDZ domain
IPR001849 Pleckstrin homology domain
IPR015212 Regulator of G protein signalling-like domain
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00621
PF00595
PF13180
PF00169
PF09128

PRINTS

PIRSF

SMART

SM00325
SM00228
SM00233
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite