Version 5.4
Homo sapiens Protein: ATF7IP
Summary
InnateDB Protein IDBP-588755.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATF7IP
Protein Name activating transcription factor 7 interacting protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000443179
InnateDB Gene IDBG-20919 (ATF7IP)
Protein Structure
UniProt Annotation
Function Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells. {ECO:0000269PubMed:12665582, ECO:0000269PubMed:14536086, ECO:0000269PubMed:19106100}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19106100}.
Disease Associations
Tissue Specificity Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding cancerous tissues (at protein level). {ECO:0000269PubMed:19106100}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 109 [view]
Protein-Protein 109 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006306 DNA methylation
GO:0006351 transcription, DNA-templated
GO:0016032 viral process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6VMQ6
PhosphoSite PhosphoSite-Q6VMQ6
TrEMBL F8WE35
UniProt Splice Variant
Entrez Gene 55729
UniGene Hs.742255
RefSeq NP_001273444
HUGO HGNC:20092
OMIM 613644
CCDS CCDS73449
HPRD 09811
IMGT
EMBL AC007782 AC008114 AC008814 AC124892 AF425650 AJ242978 AK001001 AK001550 AY337596 BC037312 BC063855
GenPept AAH37312 AAH63855 AAO91864 AAQ92978 BAA91751 CAB45135

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca