InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XRN2

Summary

InnateDB Protein

IDBP-58894.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRN2

Protein Name

5'-3' exoribonuclease 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366396

InnateDB Gene

IDBG-58892 (XRN2)

Protein Structure

UniProt Annotation

Function

Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. {ECO:0000250, ECO:0000269PubMed:15565158, ECO:0000269PubMed:16648491}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849}.

Disease Associations

Tissue Specificity

Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. {ECO:0000269PubMed:10409438, ECO:0000269PubMed:16147866}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.

Experimentally validated
Total	71 [view]
Protein-Protein	70 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004518	nuclease activity
GO:0004527	exonuclease activity
GO:0004534	5'-3' exoribonuclease activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008409	5'-3' exonuclease activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000738	DNA catabolic process, exonucleolytic
GO:0006139	nucleobase-containing compound metabolic process
GO:0006353	DNA-dependent transcription, termination
GO:0006355	regulation of transcription, DNA-templated
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0006401	RNA catabolic process
GO:0007283	spermatogenesis
GO:0016049	cell growth
GO:0016070	RNA metabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic