InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HOXC11

Summary

InnateDB Protein

IDBP-589226.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXC11

Protein Name

homeobox C11

Synonyms

HOX3H;

Species

Homo sapiens

Ensembl Protein

ENSP00000446680

InnateDB Gene

IDBG-37303 (HOXC11)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0001656	metanephros development
GO:0001759	organ induction
GO:0006351	transcription, DNA-templated
GO:0007492	endoderm development
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0042733	embryonic digit morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060272	embryonic skeletal joint morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
IPR021918 Domain of unknown function DUF3528, homeobox protein, eukaryotic

PFAM

PF00046
PF12045

PRINTS

PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt