Version 5.4
Homo sapiens Protein: MRE11A
Summary
InnateDB Protein IDBP-589257.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRE11A
Protein Name MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Synonyms ATLD; HNGS1; MRE11; MRE11B;
Species Homo sapiens
Ensembl Protein ENSP00000442809
InnateDB Gene IDBG-68191 (MRE11A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 126 [view]
Protein-Protein 119 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004527 exonuclease activity
GO:0016787 hydrolase activity
Biological Process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F5H742
UniProt Splice Variant
Entrez Gene 4361
UniGene Hs.192649
RefSeq
HUGO HGNC:7230
OMIM 600814
CCDS
HPRD 02889
IMGT
EMBL AP000765 AP000786
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca