InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHB2

Summary

InnateDB Protein

IDBP-589338.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHB2

Protein Name

prohibitin 2

Synonyms

BAP; Bap37; BCAP37; p22; PNAS-141; REA;

Species

Homo sapiens

Ensembl Protein

ENSP00000441875

InnateDB Gene

IDBG-230632 (PHB2)

Protein Structure

UniProt Annotation

Function

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. {ECO:0000250UniProtKB:O35129, ECO:0000269PubMed:10359819, ECO:0000303PubMed:11302691}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Also cytoplasmic and nuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	95 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030331	estrogen receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:0033600	negative regulation of mammary gland epithelial cell proliferation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060744	mammary gland branching involved in thelarche
GO:0060749	mammary gland alveolus development
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016363	nuclear matrix
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome