InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTHFD1

Summary

InnateDB Protein

IDBP-589432.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTHFD1

Protein Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

Synonyms

MTHFC; MTHFD;

Species

Homo sapiens

Ensembl Protein

ENSP00000450560

InnateDB Gene

IDBG-9107 (MTHFD1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	54 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004329	formate-tetrahydrofolate ligase activity
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity
GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524	ATP binding

Biological Process

GO:0000105	histidine biosynthetic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009086	methionine biosynthetic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0035999	tetrahydrofolate interconversion
GO:0044281	small molecule metabolic process
GO:0046655	folic acid metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

PFAM

PF00763
PF02882

PRINTS

PR00085

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11586