InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYT1

Summary

InnateDB Protein

IDBP-589596.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYT1

Protein Name

synaptotagmin I

Synonyms

P65; SVP65; SYT;

Species

Homo sapiens

Ensembl Protein

ENSP00000447575

InnateDB Gene

IDBG-49321 (SYT1)

Protein Structure

UniProt Annotation

Function

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0005545	1-phosphatidylinositol binding
GO:0017075	syntaxin-1 binding
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0005513	detection of calcium ion
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0014047	glutamate secretion
GO:0017157	regulation of exocytosis
GO:0051260	protein homooligomerization

Cellular Component

GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030666	endocytic vesicle membrane
GO:0030672	synaptic vesicle membrane
GO:0042584	chromaffin granule membrane
GO:0043005	neuron projection
GO:0060201	clathrin-sculpted acetylcholine transport vesicle membrane
GO:0060203	clathrin-sculpted glutamate transport vesicle membrane
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane