Homo sapiens Protein: ADM
InnateDB Protein IDBP-589740.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADM
Protein Name adrenomedullin
Synonyms AM; PAMP;
Species Homo sapiens
Ensembl Protein ENSP00000436607
InnateDB Gene IDBG-31636 (ADM)
Protein Structure
UniProt Annotation
Function AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0031700 adrenomedullin receptor binding
Biological Process
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001843 neural tube closure
GO:0002026 regulation of the force of heart contraction
GO:0002031 G-protein coupled receptor internalization
GO:0006171 cAMP biosynthetic process
GO:0006701 progesterone biosynthetic process
GO:0007165 signal transduction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0008015 blood circulation
GO:0008209 androgen metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009409 response to cold
GO:0009611 response to wounding
GO:0010033 response to organic substance
GO:0010460 positive regulation of heart rate
GO:0019933 cAMP-mediated signaling
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031100 organ regeneration
GO:0031102 neuron projection regeneration
GO:0031623 receptor internalization
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0045766 positive regulation of angiogenesis
GO:0045906 negative regulation of vasoconstriction
GO:0045909 positive regulation of vasodilation
GO:0046879 hormone secretion
GO:0048589 developmental growth
GO:0051384 response to glucocorticoid
GO:0055074 calcium ion homeostasis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060712 spongiotrophoblast layer development
GO:0097084 vascular smooth muscle cell development
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
InterPro IPR001710 Adrenomedullin
IPR021116 Procalcitonin/adrenomedullin
PFAM PF00214
Post-translational Modifications
SwissProt P35318
PhosphoSite PhosphoSite-P35318
UniProt Splice Variant
Entrez Gene 133
UniGene Hs.441047
OMIM 103275
HPRD 00061
EMBL AC080023 AK312893 BC015961 BT006902 CH471064 CR541995 D14874 D43639 DQ143945 S73906
GenPept AAC60642 AAH15961 AAP35548 AAZ38717 BAA03589 BAA07756 BAG35740 CAG46792 EAW68571 EAW68572