Version 5.4
Homo sapiens Protein: MOGAT2
Summary
InnateDB Protein IDBP-589983.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MOGAT2
Protein Name monoacylglycerol O-acyltransferase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000436537
InnateDB Gene IDBG-64956 (MOGAT2)
Protein Structure
UniProt Annotation
Function Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. {ECO:0000269PubMed:12621063}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:12621063}; Multi-pass membrane protein {ECO:0000269PubMed:12621063}.
Disease Associations
Tissue Specificity Highly expressed in liver, small intestine, colon, stomach and kidney. {ECO:0000269PubMed:12621063, ECO:0000269PubMed:12824082}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003846 2-acylglycerol O-acyltransferase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0006071 glycerol metabolic process
GO:0019432 triglyceride biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007130 Diacylglycerol acyltransferase
PFAM PF03982
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SYC2
PhosphoSite PhosphoSite-Q3SYC2
TrEMBL
UniProt Splice Variant
Entrez Gene 80168
UniGene Hs.288568
RefSeq
HUGO HGNC:23248
OMIM 610270
CCDS
HPRD 11367
IMGT
EMBL AK026297 AK128620 AK291998 AY157608 BC103876 BC103877 BC103878 CH471076
GenPept AAI03877 AAI03878 AAI03879 AAO23672 BAB15436 BAC87534 BAF84687 EAW74983

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca