InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBX3

Summary

InnateDB Protein

IDBP-59035.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBX3

Protein Name

T-box 3

Synonyms

TBX3-ISO; UMS; XHL;

Species

Homo sapiens

Ensembl Protein

ENSP00000257566

InnateDB Gene

IDBG-59033 (TBX3)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. {ECO:0000269PubMed:10468588, ECO:0000269PubMed:22002537}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00201}.

Disease Associations

Ulnar-mammary syndrome (UMS) [MIM:181450]: Characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. {ECO:0000269PubMed:10330342}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001568	blood vessel development
GO:0001701	in utero embryonic development
GO:0001947	heart looping
GO:0003007	heart morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003167	atrioventricular bundle cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007569	cell aging
GO:0008284	positive regulation of cell proliferation
GO:0008595	anterior/posterior axis specification, embryo
GO:0009887	organ morphogenesis
GO:0010159	specification of organ position
GO:0019827	stem cell maintenance
GO:0021761	limbic system development
GO:0030539	male genitalia development
GO:0030540	female genitalia development
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030879	mammary gland development
GO:0032275	luteinizing hormone secretion
GO:0035108	limb morphogenesis
GO:0035115	embryonic forelimb morphogenesis
GO:0035136	forelimb morphogenesis
GO:0042127	regulation of cell proliferation
GO:0042733	embryonic digit morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0045662	negative regulation of myoblast differentiation
GO:0045787	positive regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046884	follicle-stimulating hormone secretion
GO:0048332	mesoderm morphogenesis
GO:0055007	cardiac muscle cell differentiation
GO:0060021	palate development
GO:0060412	ventricular septum morphogenesis
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060596	mammary placode formation
GO:0060923	cardiac muscle cell fate commitment
GO:0060931	sinoatrial node cell development
GO:0090398	cellular senescence
GO:2000648	positive regulation of stem cell proliferation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001699 Transcription factor, T-box
IPR008967 p53-like transcription factor, DNA-binding
IPR022582 Transcription factor, T-box, region of unknown function

PFAM

PF00907
PF12598

PRINTS

PR00937

PIRSF

SMART

SM00425

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt