InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALDH6A1

Summary

InnateDB Protein

IDBP-591810.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH6A1

Protein Name

aldehyde dehydrogenase 6 family, member A1

Synonyms

MMSADHA; MMSDH;

Species

Homo sapiens

Ensembl Protein

ENSP00000450436

InnateDB Gene

IDBG-11882 (ALDH6A1)

Protein Structure

UniProt Annotation

Function

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

Subcellular Localization

Mitochondrion.

Disease Associations

Methylmalonate semialdehyde dehydrogenase deficiency (MMSDHD) [MIM:614105]: A metabolic disorder characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. {ECO:0000269PubMed:10947204}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0016491	oxidoreductase activity
GO:0018478	malonate-semialdehyde dehydrogenase (acetylating) activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006210	thymine catabolic process
GO:0006573	valine metabolic process
GO:0006574	valine catabolic process
GO:0008152	metabolic process
GO:0009083	branched-chain amino acid catabolic process
GO:0019859	thymine metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0050873	brown fat cell differentiation
GO:0055114	oxidation-reduction process