InnateDB Protein
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IDBP-591999.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPME1
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Protein Name
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protein phosphatase methylesterase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000441498
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InnateDB Gene
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IDBG-232998 (PPME1)
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Protein Structure
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Function |
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269PubMed:10318862}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
43
[view]
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Protein-Protein |
42
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004864
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protein phosphatase inhibitor activity
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GO:0008601
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protein phosphatase type 2A regulator activity
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GO:0019903
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protein phosphatase binding
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GO:0051721
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protein phosphatase 2A binding
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GO:0051722
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protein C-terminal methylesterase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y570
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PhosphoSite |
PhosphoSite-Q9Y570
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51400
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UniGene |
Hs.674200
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RefSeq |
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HUGO |
HGNC:30178
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OMIM |
611117
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CCDS |
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HPRD |
17864
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IMGT |
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EMBL |
AF111853
AF157028
AF193049
AK001381
AK022725
AK123288
AP000577
AP002392
BC003046
BC050705
CH471076
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GenPept |
AAD44976
AAF16692
AAG22477
AAH03046
AAH50705
BAA91661
BAC85574
BAG51108
EAW74932
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