InnateDB Protein
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IDBP-592049.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BTBD7
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Protein Name
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BTB (POZ) domain containing 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000451010
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InnateDB Gene
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IDBG-17453 (BTBD7)
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Protein Structure
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Function |
Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011705
BTB/Kelch-associated
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PFAM |
PF07707
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PRINTS |
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PIRSF |
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SMART |
SM00875
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P203
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PhosphoSite |
PhosphoSite-Q9P203
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55727
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UniGene |
Hs.637026
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RefSeq |
NP_001276062
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HUGO |
HGNC:18269
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OMIM |
610386
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CCDS |
CCDS73684
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HPRD |
12541
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IMGT |
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EMBL |
AB040958
AK001510
AK021953
AK291422
AL049394
AL122023
AL132838
BC047071
BX248762
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GenPept |
AAH47071
BAA91730
BAA96049
BAB13946
BAF84111
CAD66569
CAH10736
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