Version 5.4
Homo sapiens Protein: IL7
Summary
InnateDB Protein IDBP-592051.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL7
Protein Name interleukin 7
Synonyms IL-7;
Species Homo sapiens
Ensembl Protein ENSP00000438922
InnateDB Gene IDBG-26153 (IL7)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005126 cytokine receptor binding
GO:0005139 interleukin-7 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0030890 positive regulation of B cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045453 bone resorption
GO:0045582 positive regulation of T cell differentiation
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000226 Interleukin-7/interleukin-9 family
IPR001181 Interleukin-7
PFAM PF01415
PRINTS PR00435
PIRSF PIRSF001942
SMART SM00127
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P13232
PhosphoSite PhosphoSite-
TrEMBL Q5FBY8
UniProt Splice Variant
Entrez Gene 3574
UniGene Hs.591873
RefSeq NP_001186816
HUGO HGNC:6023
OMIM 146660
CCDS CCDS75756
HPRD 00892
IMGT
EMBL AB102879 AB102880 AB102883 AC083837 AC100854 BC047698 CH471068 EF064721 J04156 M29048 M29049 M29050 M29051 M29052 M29053
GenPept AAA59156 AAC63047 AAH47698 ABK41904 BAD89408 BAD89409 BAD89412 EAW87060 EAW87062

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca