Version 5.4
Homo sapiens Protein: BACE1
Summary
InnateDB Protein IDBP-592521.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BACE1
Protein Name beta-site APP-cleaving enzyme 1
Synonyms ASP2; BACE; HSPC104;
Species Homo sapiens
Ensembl Protein ENSP00000431848
InnateDB Gene IDBG-73181 (BACE1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 31 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001461 Aspartic peptidase
IPR009119 Peptidase A1, beta-site APP cleaving enzyme, BACE
IPR009120 Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1
IPR021109 Aspartic peptidase domain
PFAM PF00026
PRINTS PR00792
PR01815
PR01816
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H0YDX0
UniProt Splice Variant
Entrez Gene 23621
UniGene Hs.670113
RefSeq
HUGO HGNC:933
OMIM 604252
CCDS
HPRD 07255
IMGT
EMBL AP000892
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca