InnateDB Protein
|
IDBP-592708.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
DDAH1
|
Protein Name
|
dimethylarginine dimethylaminohydrolase 1
|
Synonyms
|
DDAH; HEL-S-16;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000438604
|
InnateDB Gene
|
IDBG-100049 (DDAH1)
|
Protein Structure
|
|
Function |
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle. {ECO:0000269PubMed:10493931}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
1
[view]
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0003824
|
catalytic activity
|
GO:0016403
|
dimethylargininase activity
|
GO:0016813
|
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
|
GO:0046872
|
metal ion binding
|
|
Biological Process |
GO:0000052
|
citrulline metabolic process
|
GO:0003073
|
regulation of systemic arterial blood pressure
|
GO:0006527
|
arginine catabolic process
|
GO:0007263
|
nitric oxide mediated signal transduction
|
GO:0045429
|
positive regulation of nitric oxide biosynthetic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR003198
Amidinotransferase
|
PFAM |
PF02274
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O94760
|
PhosphoSite |
PhosphoSite-O94760
|
TrEMBL |
B4E3V1
|
UniProt Splice Variant |
|
Entrez Gene |
23576
|
UniGene |
Hs.731520
|
RefSeq |
|
HUGO |
HGNC:2715
|
OMIM |
604743
|
CCDS |
CCDS705
|
HPRD |
09203
|
IMGT |
|
EMBL |
AB001915
AC092807
AK304876
AK312432
AL078459
AL360219
BC033680
BC043235
BX648145
CH471097
EU794605
|
GenPept |
AAH33680
AAH43235
ACJ13659
BAA37117
BAG35341
BAG65613
CAI45988
EAW73199
EAW73200
EAW73202
|
|
|