InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: THBS1

Summary

InnateDB Protein

IDBP-5928.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THBS1

Protein Name

thrombospondin 1

Synonyms

THBS; THBS-1; TSP; TSP-1; TSP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000260356

InnateDB Gene

IDBG-5926 (THBS1)

Protein Structure

UniProt Annotation

Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0001948	glycoprotein binding
GO:0001968	fibronectin binding
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017134	fibroblast growth factor binding
GO:0030169	low-density lipoprotein particle binding
GO:0042802	identical protein binding
GO:0043236	laminin binding
GO:0043394	proteoglycan binding
GO:0050431	transforming growth factor beta binding
GO:0050840	extracellular matrix binding
GO:0070051	fibrinogen binding
GO:0070052	collagen V binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001666	response to hypoxia
GO:0001937	negative regulation of endothelial cell proliferation
GO:0001953	negative regulation of cell-matrix adhesion
GO:0002040	sprouting angiogenesis
GO:0002544	chronic inflammatory response
GO:0002576	platelet degranulation
GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605	negative regulation of dendritic cell antigen processing and presentation
GO:0003151	outflow tract morphogenesis
GO:0003197	endocardial cushion development
GO:0003417	growth plate cartilage development
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006986	response to unfolded protein
GO:0007050	cell cycle arrest
GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0009612	response to mechanical stimulus
GO:0009749	response to glucose
GO:0010595	positive regulation of endothelial cell migration
GO:0010596	negative regulation of endothelial cell migration
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
GO:0010751	negative regulation of nitric oxide mediated signal transduction
GO:0010754	negative regulation of cGMP-mediated signaling
GO:0010757	negative regulation of plasminogen activation
GO:0010759	positive regulation of macrophage chemotaxis
GO:0010763	positive regulation of fibroblast migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016477	cell migration
GO:0016525	negative regulation of angiogenesis
GO:0018149	peptide cross-linking
GO:0030168	platelet activation
GO:0030194	positive regulation of blood coagulation
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032026	response to magnesium ion
GO:0032570	response to progesterone
GO:0032695	negative regulation of interleukin-12 production
GO:0032914	positive regulation of transforming growth factor beta1 production
GO:0033574	response to testosterone
GO:0034605	cellular response to heat
GO:0034976	response to endoplasmic reticulum stress
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327	positive regulation of phosphorylation
GO:0042493	response to drug
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043032	positive regulation of macrophage activation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0043652	engulfment of apoptotic cell
GO:0045087	innate immune response (InnateDB)
GO:0045727	positive regulation of translation
GO:0045766	positive regulation of angiogenesis
GO:0048266	behavioral response to pain
GO:0048514	blood vessel morphogenesis
GO:0050921	positive regulation of chemotaxis
GO:0051592	response to calcium ion
GO:0051895	negative regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0051918	negative regulation of fibrinolysis
GO:0071356	cellular response to tumor necrosis factor
GO:0071363	cellular response to growth factor stimulus
GO:0071636	positive regulation of transforming growth factor beta production
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000353	positive regulation of endothelial cell apoptotic process
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016529	sarcoplasmic reticulum
GO:0030141	secretory granule
GO:0031012	extracellular matrix
GO:0031091	platelet alpha granule
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000884 Thrombospondin, type 1 repeat
IPR001007 von Willebrand factor, type C
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR003367 Thrombospondin, type 3-like repeat
IPR008859 Thrombospondin, C-terminal
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR028974 TSP type-3 repeat

PFAM