InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP20

Summary

InnateDB Protein

IDBP-594452.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP20

Protein Name

Rho GTPase activating protein 20

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000431399

InnateDB Gene

IDBG-70710 (ARHGAP20)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

Subcellular Localization

Disease Associations

Note=A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes.

Tissue Specificity

Expressed predominantly in the brain. Lower expression is found in lymph nodes. {ECO:0000269PubMed:15543602}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000198 Rho GTPase-activating protein domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00620
PF00169

PRINTS

PIRSF

SMART

SM00314
SM00324
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9P2F6