InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATAD3A

Summary

InnateDB Protein

IDBP-595098.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATAD3A

Protein Name

ATPase family, AAA domain containing 3A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000439290

InnateDB Gene

IDBG-85398 (ATAD3A)

Protein Structure

UniProt Annotation

Function

Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis. {ECO:0000269PubMed:17210950, ECO:0000269PubMed:20154147, ECO:0000269PubMed:22453275}.

Subcellular Localization

Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N- terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids.

Disease Associations

Tissue Specificity

Overexpressed in lung adenocarcinomas (at protein level). {ECO:0000269PubMed:20332122}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0008152	metabolic process
GO:0016049	cell growth
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0042645	mitochondrial nucleoid

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR021911 ATPase family AAA domain-containing protein 3, domain of unknown function DUF3523
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF12037

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NVI7