Version 5.4
Homo sapiens Protein: CELF6
Summary
InnateDB Protein IDBP-595354.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CELF6
Protein Name CUGBP, Elav-like family member 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000439956
InnateDB Gene IDBG-20517 (CELF6)
Protein Structure
UniProt Annotation
Function RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA. {ECO:0000269PubMed:14761971}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed mainly in kidney, brain and testis and present in other tissues albeit at lower levels. Also expressed in fetal kidney. {ECO:0000269PubMed:14761971}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96J87
PhosphoSite PhosphoSite-Q96J87
TrEMBL
UniProt Splice Variant
Entrez Gene 60677
UniGene Hs.348342
RefSeq NP_001166156
HUGO HGNC:14059
OMIM 612681
CCDS CCDS53955
HPRD 10691
IMGT
EMBL AC009690 AF401233 AF425606 AK131098 AK294382 AK296004 BC030835 BC033838
GenPept AAH30835 AAH33838 AAK95615 AAL34513 BAC85148 BAG57639 BAG58778

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca