InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHPT1

Summary

InnateDB Protein

IDBP-595408.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHPT1

Protein Name

choline phosphotransferase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000447887

InnateDB Gene

IDBG-53342 (CHPT1)

Protein Structure

UniProt Annotation

Function

Catalyzes phosphatidylcholine biosynthesis from CDP- choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:12221122}; Multi-pass membrane protein {ECO:0000269PubMed:12221122}.

Disease Associations

Tissue Specificity

Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancerous breast epithelial cell lines. {ECO:0000269PubMed:10893425, ECO:0000269PubMed:12359261}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004142	diacylglycerol cholinephosphotransferase activity
GO:0016780	phosphotransferase activity, for other substituted phosphate groups
GO:0019992	diacylglycerol binding
GO:0046872	metal ion binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006657	CDP-choline pathway
GO:0006663	platelet activating factor biosynthetic process
GO:0008654	phospholipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process