Version 5.4
Homo sapiens Protein: CARD18
Summary
InnateDB Protein IDBP-595655.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARD18
Protein Name caspase recruitment domain family, member 18
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000436691
InnateDB Gene IDBG-547138 (CARD18)
Protein Structure
UniProt Annotation
Function Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B. {ECO:0000269PubMed:11051551}.
Subcellular Localization
Disease Associations
Tissue Specificity Primarily expressed in the heart and placenta. {ECO:0000269PubMed:11051551}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0006954 inflammatory response
GO:0010951 negative regulation of endopeptidase activity
GO:0042981 regulation of apoptotic process
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR001315 CARD domain
IPR011029 Death-like domain
PFAM PF00619
PRINTS
PIRSF
SMART SM00114
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57730
PhosphoSite PhosphoSite-P57730
TrEMBL G5EA35
UniProt Splice Variant
Entrez Gene 59082
UniGene Hs.56279
RefSeq NP_067546
HUGO HGNC:28861
OMIM 605354
CCDS CCDS53705
HPRD 16099
IMGT
EMBL AF208005 AP003181 AY358231 BC131610 CH471065
GenPept AAG23528 AAI31611 AAQ88598 EAW67065

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca