InnateDB Protein
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IDBP-596159.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BCAR3
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Protein Name
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breast cancer anti-estrogen resistance 3
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Synonyms
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NSP2; SH2D3B;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000441343
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InnateDB Gene
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IDBG-100343 (BCAR3)
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Protein Structure
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Function |
May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. {ECO:0000269PubMed:9582273}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue. {ECO:0000269PubMed:10187783, ECO:0000269PubMed:9582273}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001895
Ras guanine-nucleotide exchange factors catalytic domain
IPR023578
Ras guanine nucleotide exchange factor domain
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PFAM |
PF00617
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PRINTS |
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PIRSF |
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SMART |
SM00147
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TIGRFAMs |
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Modification |
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SwissProt |
O75815
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PhosphoSite |
PhosphoSite-O75815
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8412
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UniGene |
Hs.36958
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RefSeq |
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HUGO |
HGNC:973
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OMIM |
604704
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CCDS |
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HPRD |
05268
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IMGT |
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EMBL |
AF124250
AL049796
AL109613
AL359820
AL512488
AL833121
AY358996
BC039895
CH471097
U92715
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GenPept |
AAC39777
AAD28245
AAH39895
AAQ89355
CAH73975
CAI18950
EAW73065
EAW73066
EAW73068
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