InnateDB Protein
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IDBP-596197.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C11orf30
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Protein Name
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chromosome 11 open reading frame 30
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000432327
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InnateDB Gene
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IDBG-65156 (C11orf30)
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Protein Structure
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Function |
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. {ECO:0000269PubMed:14651845, ECO:0000269PubMed:19131338}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:14651845}. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005491
EMSY N-terminal
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PFAM |
PF03735
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z589
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PhosphoSite |
PhosphoSite-Q7Z589
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56946
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UniGene |
Hs.352588
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RefSeq |
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HUGO |
HGNC:18071
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OMIM |
608574
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CCDS |
CCDS8244
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HPRD |
10544
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IMGT |
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EMBL |
AF226047
AJ430203
AK023651
AP002360
AP003165
AY070433
BC029375
BC033404
BC117265
BC143370
BC143374
BC143376
CH471076
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GenPept |
AAF86947
AAH29375
AAH33404
AAI17266
AAI43371
AAI43375
AAI43377
AAL65260
BAB14627
CAD22881
EAW74998
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