InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCYL1

Summary

InnateDB Protein

IDBP-596407.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCYL1

Protein Name

SCY1-like 1 (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000437254

InnateDB Gene

IDBG-57084 (SCYL1)

Protein Structure

UniProt Annotation

Function

Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. {ECO:0000269PubMed:18556652}.Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269PubMed:18556652}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:18556652}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269PubMed:18556652}. Golgi apparatus, cis-Golgi network {ECO:0000269PubMed:18556652}. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.Isoform 1: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.Isoform 2: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.Isoform 3: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.Isoform 6: Nucleus {ECO:0000269PubMed:15504359}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:12036289}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005488	binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0005815	microtubule organizing center
GO:0016020	membrane
GO:0030126	COPI vesicle coat

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96KG9