InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C9orf89

Summary

InnateDB Protein

IDBP-596504.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C9orf89

Protein Name

chromosome 9 open reading frame 89

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000437237

InnateDB Gene

IDBG-76473 (C9orf89)

Protein Structure

UniProt Annotation

Function

Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. {ECO:0000269PubMed:15637807}.

Subcellular Localization

Isoform 1: Nucleus {ECO:0000269PubMed:23633586}. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.Isoform 2: Endoplasmic reticulum membrane {ECO:0000269PubMed:23633586}; Single-pass membrane protein {ECO:0000269PubMed:23633586}. Mitochondrion membrane {ECO:0000269PubMed:23633586}; Single-pass membrane protein {ECO:0000269PubMed:23633586}.

Disease Associations

Tissue Specificity

Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain. {ECO:0000269PubMed:15637807}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0050700	CARD domain binding

Biological Process

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component

GO:0005634	nucleus
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane