Homo sapiens Protein: FICD
Summary
InnateDB Protein IDBP-596518.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FICD
Protein Name FIC domain containing
Synonyms HIP13; HYPE; UNQ3041;
Species Homo sapiens
Ensembl Protein ENSP00000446479
InnateDB Gene IDBG-55299 (FICD)
Protein Structure
UniProt Annotation
Function Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified. {ECO:0000269PubMed:19362538, ECO:0000269PubMed:22266942}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:19362538}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0070733 protein adenylyltransferase activity
Biological Process
GO:0018117 protein adenylylation
GO:0034259 negative regulation of Rho GTPase activity
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003812 Fido domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
PFAM PF02661
PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BVA6
PhosphoSite PhosphoSite-Q9BVA6
TrEMBL A0A024RBM8
UniProt Splice Variant
Entrez Gene 11153
UniGene Hs.661891
RefSeq NP_009007
HUGO HGNC:18416
OMIM
CCDS CCDS9116
HPRD 13723
IMGT
EMBL AF049611 AY358992 BC001342 CH471054
GenPept AAC26847 AAH01342 AAQ89351 EAW97813 EAW97815