Version 5.4
Homo sapiens Protein: VNN3
Summary
InnateDB Protein IDBP-596685.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VNN3
Protein Name vanin 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000441182
InnateDB Gene IDBG-96673 (VNN3)
Protein Structure
UniProt Annotation
Function Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. {ECO:0000269PubMed:11491533}.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Note=According to PubMed:11491533, secreted. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with higher expression in liver and blood. Expressed in differentiated keratinocytes in epidermis and in epithelial cells in dermis. Overexpressed in lesional psoriatic skin. {ECO:0000269PubMed:11491533, ECO:0000269PubMed:19322213}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0017159 pantetheine hydrolase activity
Biological Process
GO:0006807 nitrogen compound metabolic process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003010 Carbon-nitrogen hydrolase
PFAM PF00795
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NY84
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 55350
UniGene Hs.183656
RefSeq
HUGO HGNC:16431
OMIM 606592
CCDS
HPRD 09420
IMGT
EMBL AB435052 AB435053 AB435054 AB435055 AB435056 AB435057 AB435058 AB435059 AB435060 AB435061 AJ238982 AL032821 BC104416 BC104417 CH471051 DQ220706
GenPept AAI04417 AAI04418 ABA60895 BAG30924 BAG30925 BAG30926 BAG30927 BAG30928 BAG30929 BAG30930 BAG30931 BAG30932 BAG30933 CAB76824 EAW48017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca