InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VDR

Summary

InnateDB Protein

IDBP-597039.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VDR

Protein Name

vitamin D (1,25- dihydroxyvitamin D3) receptor

Synonyms

NR1I1; PPP1R163;

Species

Homo sapiens

Ensembl Protein

ENSP00000447173

InnateDB Gene

IDBG-29237 (VDR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 184 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	184 [view]
Protein-Protein	156 [view]
Protein-DNA	26 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008434	vitamin D3 receptor activity
GO:0038186	lithocholic acid receptor activity
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding
GO:0070644	vitamin D response element binding
GO:1902098	calcitriol binding
GO:1902121	lithocholic acid binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007595	lactation
GO:0008285	negative regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0010467	gene expression
GO:0010628	positive regulation of gene expression
GO:0010839	negative regulation of keratinocyte proliferation
GO:0010980	positive regulation of vitamin D 24-hydroxylase activity
GO:0038183	bile acid signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046697	decidualization
GO:0050892	intestinal absorption
GO:0060058	positive regulation of apoptotic process involved in mammary gland involution
GO:0060558	regulation of calcidiol 1-monooxygenase activity
GO:0060745	mammary gland branching involved in pregnancy
GO:0070561	vitamin D receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000324 Vitamin D receptor
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00350
PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt