InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYB5A

Summary

InnateDB Protein

IDBP-597075.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYB5A

Protein Name

cytochrome b5 type A (microsomal)

Synonyms

CYB5; MCB5;

Species

Homo sapiens

Ensembl Protein

ENSP00000436461

InnateDB Gene

IDBG-4942 (CYB5A)

Protein Structure

UniProt Annotation

Function

Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

Subcellular Localization

Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.Isoform 2: Cytoplasm.

Disease Associations

Methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:250790]: A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. {ECO:0000269PubMed:8168836}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004033	aldo-keto reductase (NADP) activity
GO:0004129	cytochrome-c oxidase activity
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0019852	L-ascorbic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome