Version 5.4
Homo sapiens Protein: NAV2
Summary
InnateDB Protein IDBP-597129.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAV2
Protein Name neuron navigator 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000437316
InnateDB Gene IDBG-35624 (NAV2)
Protein Structure
UniProt Annotation
Function Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269PubMed:12214280, ECO:0000269PubMed:15158073}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12214280}.
Disease Associations
Tissue Specificity Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers. {ECO:0000269PubMed:11904404, ECO:0000269PubMed:12062803, ECO:0000269PubMed:12079279, ECO:0000269PubMed:12214280}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003593 AAA+ ATPase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IVL1
PhosphoSite PhosphoSite-Q8IVL1
TrEMBL E9PLU3
UniProt Splice Variant
Entrez Gene 89797
UniGene Hs.623782
RefSeq NP_001104489
HUGO HGNC:15997
OMIM 607026
CCDS CCDS44552
HPRD 07385
IMGT
EMBL AB037840 AB063115 AB063116 AC009549 AC015684 AC023950 AC090662 AC111163 AC113193 AF466143 AF466144 AJ488102 AJ488203 AJ488204 AJ488205 AJ488206 AJ488207 AJ488208 AK001495 AK001892 AK074287 BC016054
GenPept AAH16054 AAL96479 AAL96480 BAA91723 BAA91965 BAA92657 BAB85038 BAC00853 BAC00854 CAD32471 CAD32556 CAD32557 CAD32558 CAD32559 CAD32560 CAD32561

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca