Version 5.4
Homo sapiens Protein: PCOLCE2
Summary
InnateDB Protein IDBP-59767.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCOLCE2
Protein Name procollagen C-endopeptidase enhancer 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295992
InnateDB Gene IDBG-59765 (PCOLCE2)
Protein Structure
UniProt Annotation
Function Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1. {ECO:0000269PubMed:12393877}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland, trachea and placenta and weakly expressed in the brain. Expressed in cartilage. {ECO:0000269PubMed:10873381, ECO:0000269PubMed:11597177, ECO:0000269PubMed:12393877}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008201 heparin binding
GO:0016504 peptidase activator activity
Biological Process
GO:0010952 positive regulation of peptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000859 CUB domain
IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
PFAM PF00431
PF01759
PRINTS
PIRSF
SMART SM00042
SM00643
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UKZ9
PhosphoSite PhosphoSite-Q9UKZ9
TrEMBL H7C5D5
UniProt Splice Variant
Entrez Gene 26577
UniGene Hs.8944
RefSeq NP_037495
HUGO HGNC:8739
OMIM 607064
CCDS CCDS3127
HPRD 06139
IMGT
EMBL AC021074 AC022291 AF098269 AK315121 AY035400 AY358557 CH471052 CR536570
GenPept AAF04621 AAK63128 AAQ88921 BAG37576 CAG38807 EAW78961 EAW78962

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca