InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP17

Summary

InnateDB Protein

IDBP-597679.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP17

Protein Name

matrix metallopeptidase 17 (membrane-inserted)

Synonyms

MT4-MMP;

Species

Homo sapiens

Ensembl Protein

ENSP00000441106

InnateDB Gene

IDBG-65039 (MMP17)

Protein Structure

UniProt Annotation

Function

Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.

Subcellular Localization

Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008047	enzyme activator activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0043085	positive regulation of catalytic activity

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005887	integral component of plasma membrane
GO:0031012	extracellular matrix
GO:0031225	anchored component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References