InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSMA6

Summary

InnateDB Protein

IDBP-597938.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMA6

Protein Name

proteasome (prosome, macropain) subunit, alpha type, 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000444844

InnateDB Gene

IDBG-4735 (PSMA6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	137 [view]
Protein-Protein	137 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004175	endopeptidase activity
GO:0004298	threonine-type endopeptidase activity
GO:0005515	protein binding
GO:0035639	purine ribonucleoside triphosphate binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0050727	regulation of inflammatory response
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005839	proteasome core complex
GO:0005844	polysome
GO:0016363	nuclear matrix
GO:0019773	proteasome core complex, alpha-subunit complex
GO:0030016	myofibril
GO:0030017	sarcomere
GO:0070062	extracellular vesicular exosome