InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR3B

Summary

InnateDB Protein

IDBP-598460.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR3B

Protein Name

polymerase (RNA) III (DNA directed) polypeptide B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000445721

InnateDB Gene

IDBG-54798 (POLR3B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0032549	ribonucleoside binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0006385	transcription elongation from RNA polymerase III promoter
GO:0006386	termination of RNA polymerase III transcription
GO:0010467	gene expression
GO:0032481	positive regulation of type I interferon production
GO:0032728	positive regulation of interferon-beta production
GO:0045087	innate immune response
GO:0045089	positive regulation of innate immune response
GO:0051607	defense response to virus

Cellular Component

GO:0005654	nucleoplasm
GO:0005666	DNA-directed RNA polymerase III complex
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6
IPR007641 RNA polymerase Rpb2, domain 7
IPR007642 RNA polymerase Rpb2, domain 2
IPR007644 RNA polymerase, beta subunit, protrusion
IPR007645 RNA polymerase Rpb2, domain 3
IPR007646 RNA polymerase Rpb2, domain 4
IPR007647 RNA polymerase Rpb2, domain 5

PFAM